SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state.

@article{Bilodeau2009SetDB1CT,
  title={SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state.},
  author={Steve Bilodeau and Michael H Kagey and Garrett M. Frampton and Peter B. Rahl and Richard A. Young},
  journal={Genes & development},
  year={2009},
  volume={23 21},
  pages={2484-9}
}
Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin regulators that help maintain ES cells are less well understood. A high-throughput shRNA screen was used to identify novel chromatin regulators that influence ES cell state. Loss of histone H3 Lys 9 (H3K9) methyltransferases, particularly SetDB1, had the most profound effects on ES cells. Chromatin immunoprecipitation (ChIP) coupled with massively parallel DNA… CONTINUE READING
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