Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.

@article{Nishioka2002Set9AN,
  title={Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.},
  author={Kenichi Nishioka and Sergei Chuikov and Kavitha Sarma and Hediye Erdjument-Bromage and C David Allis and Paul Tempst and Danny F Reinberg},
  journal={Genes & development},
  year={2002},
  volume={16 4},
  pages={479-89}
}
A novel histone methyltransferase, termed Set9, was isolated from human cells. Set9 contains a SET domain, but lacks the pre- and post-SET domains. Set9 methylates specifically lysine 4 (K4) of histone H3 (H3-K4) and potentiates transcription activation. The histone H3 tail interacts specifically with the histone deacetylase NuRD complex. Methylation of histone H3-K4 by Set9 precludes the association of NuRD with the H3 tail. Moreover, methylation of H3-K4 impairs Suv39h1-mediated methylation… CONTINUE READING
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