Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.

@article{Strahl2002Set2IA,
  title={Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.},
  author={Brian D. Strahl and Patrick A. Grant and Scott D Briggs and Zu-Wen Sun and James R. Bone and Jennifer A. Caldwell and Sahana A Mollah and Richard G. Cook and Jeffrey Shabanowitz and Donald F. Hunt and C David Allis},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 5},
  pages={1298-306}
}
Recent studies of histone methylation have yielded fundamental new insights pertaining to the role of this modification in gene activation as well as in gene silencing. While a number of methylation sites are known to occur on histones, only limited information exists regarding the relevant enzymes that mediate these methylation events. We thus sought to identify native histone methyltransferase (HMT) activities from Saccharomyces cerevisiae. Here, we describe the biochemical purification and… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 199 extracted citations

Similar Papers

Loading similar papers…