Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.

@article{Bae2013SestrinsAN,
  title={Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.},
  author={Soo Han Bae and Su Haeng Sung and Sue Young Oh and Jung Mi Lim and Se Kyoung Lee and Young Nyun Park and Hye Eun Lee and Dongmin Kang and Sue Goo Rhee},
  journal={Cell metabolism},
  year={2013},
  volume={17 1},
  pages={73-84}
}
Sestrins (Sesns) protect cells from oxidative stress. The mechanism underlying the antioxidant effect of Sesns has remained unknown, however. The Nrf2-Keap1 pathway provides cellular defense against oxidative stress by controlling the expression of antioxidant enzymes. We now show that Sesn1 and Sesn2 interact with the Nrf2 suppressor Keap1, the autophagy substrate p62, and the ubiquitin ligase Rbx1 and that the antioxidant function of Sesns is mediated through activation of Nrf2 in a manner… CONTINUE READING
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Feedback on fat : p 62 - mTORC 1 - autophagy connections

  • U. Ozcan, L. Ozcan, +4 authors G. S. Hotamisligil
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