Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.

  title={Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.},
  author={Seung-Hyun Ro and Ian A. Semple and Haewon Park and Haeli Park and H. Park and Myungjin Kim and Jeong Sig Kim and Jun Hee Lee},
  journal={The FEBS journal},
  volume={281 17},
Autophagy is a homeostatic process that is important for degrading protein aggregates, nutrient deposits, dysfunctional organelles and several signaling molecules. p62/sequestosome-1 is a protein that binds to several autophagy substrates, such as ubiquitinated proteins, damaged mitochondria and signaling molecules such as an Nrf2 inhibitor Keap1, promoting their autophagic degradation. Sestrin2, a stress-inducible protein, has recently been shown to bind to p62 and promote autophagic… CONTINUE READING


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