Sesquiterpenoids isolated from the flower buds of Tussilago farfara L. inhibit diacylglycerol acyltransferase.

@article{Park2008SesquiterpenoidsIF,
  title={Sesquiterpenoids isolated from the flower buds of Tussilago farfara L. inhibit diacylglycerol acyltransferase.},
  author={Hye Ran Park and Mi Young Yoo and Jee Hee Seo and Il Soon Kim and Nam Ye Kim and Ji Yun Kang and Long Cui and Chang-Soo Lee and Chul-Ho Lee and Hyun Sun Lee},
  journal={Journal of agricultural and food chemistry},
  year={2008},
  volume={56 22},
  pages={10493-7}
}
Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT), which is a key enzyme in triglyceride synthesis in eukaryotic organisms, has been proposed as one of the drug targets for treating obesity, type II diabetes mellitus, and metabolic syndrome. Bioassay-guided fractionation of EtOH extract of the flower buds of Tussilago farfara , using an in vitro DGAT enzyme assay, resulted in the isolation of four known sesquiterpenoids, tussilagonone (1), tussilagone (2), 7beta-(3-ethyl-cis… CONTINUE READING