Sesquiterpenes from Vladimiria souliei and their inhibitory effects on NO production.

@article{Xu2011SesquiterpenesFV,
  title={Sesquiterpenes from Vladimiria souliei and their inhibitory effects on NO production.},
  author={Jing Xu and Da‐qin Jin and Dongdong Shi and Yonggang Ma and Bo Yang and Peng Zhao and Yuanqiang Guo},
  journal={Fitoterapia},
  year={2011},
  volume={82 3},
  pages={
          508-11
        }
}
As a part of our ongoing search for plant-derived compounds that inhibit nitric oxide production, the methanol extract of the roots of Vladimiria souliei was found to show significant inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the extract yielded two most active sesquiterpenes, including a new compound, named souliene A (1) and alismol (2). Their structures were elucidated by spectroscopic methods (IR, ESIMS… 
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TLDR
A new sesquiterpene lactone and three known compounds were isolated from the roots of Vladimiria souliei and their structures were elucidated by spectroscopic methods.
Two carabrane-type sesquiterpenes from Vladimiria souliei
Abstract Two new carabrane sesquiterpenes, 4,8-dioxo-6β-methoxy-7β,11-epoxy carabrane ( 1 ), and its isomer, 4,8-dioxo-6β-methoxy-7α,11-epoxy carabrane ( 2 ) were isolated from the roots of
Sesquiterpene lactones from Vladimiria souliei.
Abstract Chemical investigation of the underground parts of Vladimiria souliei from Sichuan province, southwest China, afforded nine new sesquiterpene lactones as well as 11 known ones. The structure
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TLDR
Compounds 2 and 4 exhibited modest antimicrobial activity against Escherichia coli, Candida albicans, Pseudomonas aeruginosa, Enterococcus faecalis, Bacillus cereus, and Staphylococcus aureus.
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The polar parts of the title plant gave several lignans including six new ones named vladinol A-F. The structures were elucidated by high field (1)H-NMR spectroscopy and a few chemical reactions. The
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Three new compounds curcuminol F, G and wenyujinoside and a known compound aurantiamide are isolated from the ethanol extract of the radixes of Curcuma wenyujin by Chen et C. Ling.
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Two guaiane-type sesquiterpenoids named orientalol E (1) and orientalol F (3) were isolated from the rhizome of Alisma orientalis (SAM) JUZEP together with two known guaiane-type sesquiterpenoids
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Three new beta-dihydroagarofuran sesquiterpene esters isolated from the fruits of Celastrus orbiculatus THUNB showed moderate activity in inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.
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TLDR
A brief overview will discuss some possible interventions in the L‐arginine:NO pathway and the potential benefits as well as undesirable side effects that might arise from them.
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TLDR
It is suggested that NO is produced primarily by CD14+ synoviocytes, chondrocytes, and endothelial cells in inflammatory joints of arthritides, and can be upregulated by cytokines present in inflamed joints.
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