Sesquiterpene lactones: adverse health effects and toxicity mechanisms.

@article{Amorim2013SesquiterpeneLA,
  title={Sesquiterpene lactones: adverse health effects and toxicity mechanisms.},
  author={Marco Amorim and Rui M Gil da Costa and Carlos Frederico Costa Lopes and Margarida M. S. M. Bastos},
  journal={Critical reviews in toxicology},
  year={2013},
  volume={43 7},
  pages={559-79}
}
Sesquiterpene lactones (STLs) present a wide range of biological activities, mostly based on their alkylating capabilities, which underlie their therapeutic potential. These compounds are the active constituents of a variety of plants, frequently used as herbal remedies. STLs such as artemisinin and its derivatives are in use as first-line antimalarials while others, such as parthenolide, have recently reached cancer clinical trials. However, the toxicological profile of these compounds must be… CONTINUE READING
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