Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-kappaB.

@article{Oka2007SesquiterpeneLP,
  title={Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-kappaB.},
  author={Daizo Oka and Kazuo Nishimura and Masahiro Shiba and Yasutomo Nakai and Yasuyuki Arai and Masashi Nakayama and Hitoshi Takayama and Hitoshi Inoue and Akihiko Okuyama and Norio Nonomura},
  journal={International journal of cancer},
  year={2007},
  volume={120 12},
  pages={2576-81}
}
The transcription factor nuclear factor-kappaB (NF-kappaB) has been shown to be constitutively activated in various human malignancies, including leukemia, lymphoma and a number of solid tumors. NF-kappaB regulates the transcriptional of genes important for tumor invasion, metastasis and chemoresistance. The sesquiterpene lactone parthenolide, an inhibition of NF-kappaB, has been used conventionally to treat migraines and inflammation. In this study, renal cancer cell lines OUR-10 and ACHN were… CONTINUE READING