Sesquiterpene lactone engineering in microbial and plant platforms: parthenolide and artemisinin as case studies

@article{Majdi2015SesquiterpeneLE,
  title={Sesquiterpene lactone engineering in microbial and plant platforms: parthenolide and artemisinin as case studies},
  author={Mohammad Majdi and Morahem Ashengroph and Mohammad Reza Abdollahi},
  journal={Applied Microbiology and Biotechnology},
  year={2015},
  volume={100},
  pages={1041-1059}
}
Sesquiterpene lactones (SLs) are one of the most diverse groups of secondary metabolites that mainly have been observed in the Asteraceae. They are composed of a C15 skeleton bearing functional groups, e.g., hydroxy, keto, or epoxy. Sesquiterpene lactones have been shown to display several biological activities; hence, their therapeutic effects are indispensable. To overcome low yield of sesquiterpene lactone content in native plants, manipulation of their biosynthetic pathway(s) has become an…