Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways.

@article{Zeng2014SesquiterpeneD,
  title={Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways.},
  author={Ke-Wu Zeng and Shu Mei Wang and Hongxia Zhao and Yong Jiang and Pengfei Tu},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2014},
  volume={21 3},
  pages={298-306}
}
Microglia-involved neuroinflammation is thought to promote brain damage in various neurodegenerative disorders. Therefore, novel therapeutics suppressing microglia over-activation could prove useful for neuroprotection in inflammation-mediated neurodegenerative diseases. DSF-52 is a novel sesquiterpene dimer compound isolated from medical plant Artemisia argyi by our group. In this study, we investigated whether DSF-52 inhibited the neuroinflammatory responses in lipopolysaccharide (LPS… CONTINUE READING
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