Sesquiterpene constituents from the soft coral Sinularia nanolobata

@article{Ngoc2017SesquiterpeneCF,
  title={Sesquiterpene constituents from the soft coral Sinularia nanolobata},
  author={Ninh Thi Ngoc and Pham Thi Thu Huong and Nguyen Van Thanh and Nguyen Xuan Cuong and Nguyen Hoai Nam and Do Cong Thung and Phan Van Kiem and Ch{\^a}u Văn Minh},
  journal={Natural Product Research},
  year={2017},
  volume={31},
  pages={1799 - 1804}
}
Abstract Using various chromatographic separations, four sesquiterpenes (1–4), including two new compounds, nanolobatols A and B (1 and 2), were isolated from the Vietnamese soft coral Sinularia nanolobata. Their structures were determined on the basis of spectroscopic data (1H and 13C NMR, HSQC, HMBC, 1H–1H COSY, NOESY and FT-ICR-MS) and by comparison with the literature values. The cytotoxic activity of isolated compounds against a panel of eight human cancer cell lines was also evaluated. 
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References

SHOWING 1-10 OF 15 REFERENCES
Nanolobatolide, a new C18 metabolite from the Formosan soft coral Sinularia nanolobata.
TLDR
Nanolobatolide (1), possessing a novel C(18) molecular structure, was isolated from the Formosan soft coral Sinularia nanolobata and has been found to possess significant anti-neuroinflammatory and neuroprotective activities.
Steroid Constituents from the Soft Coral Sinularia nanolobata.
Six steroids (1-6), including the two new compounds 3β,4α-dihydroxyergosta-5,24(28)-diene (1) and 24(S),28-epoxyergost-5-ene-3β,4α-diol (2), were isolated from the methanol extract of the Vietnamese
Isolation of a new cytotoxic polyhydroxysterol from the South China Sea soft coral Sinularia sp.
TLDR
Preliminary structure–activity relationship study identified that the presence of double bonds in the side chains of these polyhydroxysterols significantly reduced the biological effect obtained.
New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for
Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata
Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral
New β-Caryophyllene-Derived Terpenoids from the Soft Coral Sinularia nanolobata
TLDR
The cytotoxicity of 1−6 against the growth of a limited panel of cancer cell lines is described and the structures of 1+5 were elucidated on the basis of extensive spectroscopic analyses and by comparison of the spectral data with those of the related metabolites.
Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata
TLDR
Two new cubitanoids and three new cembranoids, nanolobols A–C, as well as six known compounds, calyculone I, sinulariuol A (7), sinulariols C, D, H, and J (8–11), were isolated from the soft coral Sinularia nanlobata and their structures were elucidated on the basis of extensive spectroscopic analysis.
Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata
TLDR
The structures of these metabolites were elucidated on the basis of extensive spectroscopic analysis and the anti-HCMV activity of 1–4 and its cytotoxicity against selected cell lines were evaluated.
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