Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products.

@article{Harikumar2010SesaminMC,
  title={Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products.},
  author={Kuzhuvelil B Harikumar and Bokyung Sung and Sheeja T Tharakan and Manoj Kumar Pandey and Beena Joy and Sushovan Guha and Sunil Krishnan and Bharat Bhushan Aggarwal},
  journal={Molecular cancer research : MCR},
  year={2010},
  volume={8 5},
  pages={751-61}
}
Agents that are safe, affordable, and efficacious are urgently needed for the prevention of chronic diseases such as cancer. Sesamin, a lipid-soluble lignan, is one such agent that belongs to a class of phytoestrogens, isolated from sesame (Sesamum indicum), and has been linked with prevention of hyperlipidemia, hypertension, and carcinogenesis through an unknown mechanism. Because the transcription factor NF-kappaB has been associated with inflammation, carcinogenesis, tumor cell survival… CONTINUE READING

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