Serum zinc, senile plaques, and neurofibrillary tangles: findings from the Nun Study.

@article{Tully1995SerumZS,
  title={Serum zinc, senile plaques, and neurofibrillary tangles: findings from the Nun Study.},
  author={C L Tully and David A. Snowdon and William R. Markesbery},
  journal={Neuroreport},
  year={1995},
  volume={6 16},
  pages={2105-8}
}
Zinc appears to have a role in binding amyloid precursor protein in vitro, but it is not known whether zinc plays a role in senile plaque formation in vivo in humans. Serum zinc concentrations were available from 12 sisters who died in the Nun Study, a longitudinal study of aging and Alzheimer's disease. Fasting serum zinc concentrations, determined approximately 1 year before death, showed moderate to strong negative correlations with senile plaque counts in seven brain regions. In all brain… CONTINUE READING

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