Serum tryptase measurements in patients with myelodysplastic syndromes.

  title={Serum tryptase measurements in patients with myelodysplastic syndromes.},
  author={Wolfgang R Sperr and B Stehberger and Friedrich Wimazal and Mehrdad Baghestanian and Lawrence B. Schwartz and Michael Kundi and Hans Semper and John Hendrik Jordan and Andreas Chott and Johannes Drach and Ulrich Jaeger and Klaus Geissler and Annette Greschniok and H P Horny and Klaus Lechner and Peter Valent},
  journal={Leukemia & lymphoma},
  volume={43 5},
Abnormal differentiation and maturation of hemopoietic cells are characteristic features of myelodysplastic syndromes (MDS). Tryptases (alpha- and beta-type) are lineage-restricted serine proteases primarily expressed in mast cells (MC). We have analyzed expression of tryptase in 89 de novo MDS patients (refractory anemia (RA), n = 30; RA with ringed sideroblasts (RARS), n = 21; RA with excess of blasts (RAEB/RAEB-t), n = 27; chronic myelomonocytic leukemia (CMML), n = 11). Serum levels of… CONTINUE READING
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