Serum true insulin concentration and the risk of clinical non-insulin dependent diabetes during long-term follow-up.

@article{Perry1999SerumTI,
  title={Serum true insulin concentration and the risk of clinical non-insulin dependent diabetes during long-term follow-up.},
  author={Ivan J Perry and Sasiwarang Goya Wannamethee and A. Gerald Shaper and Kurt George M M Alberti},
  journal={International journal of epidemiology},
  year={1999},
  volume={28 4},
  pages={735-41}
}
BACKGROUND There is considerable evidence that insulin resistance with compensatory hyperinsulinaemia is an early and modifiable defect in the pathogenesis of non-insulin dependent diabetes (NIDDM). Current data, however, are largely based on studies that have used insulin assays which cross-react with proinsulin and other insulin precursors. Using a specific assay, we have addressed the hypothesis that an elevation of serum true insulin concentration, reflecting insulin resistance, is an early… CONTINUE READING