Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors.

@article{Tavares2004SerumTH,
  title={Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors.},
  author={Edelweiss F Tavares and Jo{\~a}o Paulo Botelho Vieira-Filho and Adagmar Andriolo and Ana Beatriz Alvarez Perez and Naja Vergani and Adriana Sanudo and Suely Godoy Agostinh Gimeno and La{\'e}rcio Joel Franco},
  journal={Ethnicity & disease},
  year={2004},
  volume={14 1},
  pages={49-56}
}
Hyperhomocysteinemia is a risk factor for cardiovascular disease. C677T mutation at the MTHFR gene and deficiencies of folic acid and vitamin B-12 may account for elevation of total homocysteine (tHcy). Ninety Brazilian Parkatêjê Indians (90.0% of the population without admixture, aged > or = 20 years) were studied. Hyperhomocysteinemia was observed in 26.7% of the Indians. No case of vitamin B-12 deficiency was detected. Folic acid deficiency was found in 43.3% of the subjects. Rates of… CONTINUE READING
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