Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer

  title={Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer},
  author={Taner Korkmaz and Selcuk E. Seber and Kerem Okutur and Gul Atalay Basaran and Fulden P. Yumuk and Faysal Dane and Tunc Ones and Ozge Polat and Ozlem Cakir Madenci and Gokhan Demir and Nazım Serdar Turhal},
  pages={88 - 94}
Context: TK1 found to be elevated biomarker in many solid cancers. Objectives: The study aimed to assess the prognostic significance of a serum TK1 in patients with metastatic NSCLC. Methods: The study included 48 consecutive patients, newly diagnosed with metastatic NSCLC, and 10 healthy volunteers. Serum TK1 activity determined by ELISA method. Results: Patients with a bTK1 level >156 Du L–1 had significantly shorter survival. TK1 level showed a strong correlation with primary tumor SUVmax… 

Serum Thymidine Kinase 1 Activity in the Prognosis and Monitoring of Chemotherapy in Lung Cancer Patients: A Brief Report

  • B. NismanH. Nechushtan T. Peretz
  • Medicine, Biology
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • 2014
Elevated pretreatment serum TK1 activity was an independent, adverse prognostic factor, based on survival, in the two main histological types of LC.

Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial

Results suggest that TK1 activity measured by DiviTum™ predicted therapy response, PFS and OS in loco regional inoperable or disseminated breast cancer, and this factor is a useful serum marker.

TK1 overexpression is associated with the poor outcomes of lung cancer patients: a systematic review and meta-analysis.

The TK1 expression might have a supportive implication in assessing biological behavior and prognosis of lung cancer patients and be associated with poorer overall survival in patients with lung cancer.

Serum thymidine kinase 1 activity as a pharmacodynamic marker of cyclin-dependent kinase 4/6 inhibition in patients with early-stage breast cancer receiving neoadjuvant palbociclib

Serum TK1 activity is a promising pharmacodynamic marker of palbociclib in ER+ breast cancer, and its value in predicting response to CDK4/6 inhibitors warrants further investigation.

The assay and clinical significance of serum thymidine kinase 1 in patients with colorectal carcinoma

The detection of serum thymidine kinase 1 might have high clinical value in auxiliary diagnosis, curative effect monitoring, and prognosis judgment of colorectal carcinoma.

Diagnostic implications of the molecular forms and levels of serum thymidine kinase 1 in different canine malignancies

Overall, the results demonstrate that TK1 protein assays provide valuable diagnostic information in a variety of canine malignancies.

Elevated transcriptional levels of aldolase A (ALDOA) associates with cell cycle-related genes in patients with NSCLC and several solid tumors

ALDOA could contribute to the progress of cancer, at least partially through its association with genes relevant to cell cycle independent of glycolysis, as well as with CDC45 and CCNB2 in breast tumors.

Screening of Critical Genes in Lung Adenocarcinoma via Network Analysis of Gene Expression Profile

A number of differentially expressed genes (DEGs) were identified for lung adenocarcinoma via comparative analysis of gene expression data, beneficial in deepening the understandings about the pathogenesis and providing directions for future researches.

Changed Expression of Cytoskeleton Proteins During Lung Injury in a Mouse Model of Streptococcus pneumoniae Infection

Important changes in the protein profiles during pneumococcal infection mainly associated with regulation of vesicle-mediated transport, wound healing, and cytoskeleton organization are found.



Prognostic factors in advanced non-small cell lung cancer: elevated serum levels of neuron specific enolase indicate poor prognosis.

Results indicate that analysis of prognostic factors including serum levels of NSE is useful for predicting the survival of patients with advanced NSCLC.

Thymidine kinase 1 in serum predicts increased risk of distant or loco-regional recurrence following surgery in patients with early breast cancer.

The results indicate that the S-TK1 concentration is higher in patients developing distant and/or loco-regional recurrence 3 months post-surgery.

Prognostic value of cytosolic thymidine kinase activity as a marker of proliferation in breast cancer.

Thymidine Kinase 1 is a Potential Marker for Prognosis and Monitoring the Response to Treatment of Patients with Breast, Lung, and Esophageal Cancer and Non-Hodgkin's Lymphoma

In a health screening study of 12,641 persons, STK1p seemed to predict the risk of development of neoplasia related diseases at early stage.

Prognostic value of histology in patients with non-small cell lung cancer.

Serum thymidine kinase 1 correlates to clinical stages and clinical reactions and monitors the outcome of therapy of 1,247 cancer patients in routine clinical settings

The concentration of TK1 in serum correlates to clinical stages and clinical reactions and monitors the effect of tumor therapies, not only in controlled clinical trials, but also in routine clinical settings.

Activity of serum thymidine kinase in non-Hodgkin lymphoma: Relationship to other prognostic factors

The results indicate that TK might be a worthful parameter to estimate progression and response to therapy of NHL and correlated better with Binet stages than blood sedimentation rate.

Prognostic factors in non-small cell lung cancer.

The purpose of this work is to review the modern literature with regard to prognostic factors for patients with non-small-cell lung cancer taking into account ongoing advances in clinical evaluation, staging, surgery, radiation therapy, chemotherapy, and molecular biology in this widely heterogeneous patient population.

Risk classification for large cell lymphoma using lactate dehydrogenase, beta-2 microglobulin, and thymidine kinase.

The addition of thymidine kinase permits a more precise estimate of risk, contributing to the utility of a serological staging system for large cell lymphoma.

Lung cancer proliferation correlates with [F-18]fluorodeoxyglucose uptake by positron emission tomography.

  • H. VesselleR. Schmidt D. Wood
  • Medicine
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2000
FDG PET may be used to noninvasively assess NSCLC proliferation in vivo, identifying rapidly growing NSCLCs with poor prognosis that could benefit from preoperative chemotherapy.