Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer

@article{Korkmaz2013SerumTK,
  title={Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer},
  author={Taner Korkmaz and Selcuk E. Seber and Kerem Okutur and Gul Atalay Basaran and Fulden P. Yumuk and Faysal Dane and Tunc Ones and Ozge Polat and Ozlem Cakir Madenci and Gokhan Demir and Nazım Serdar Turhal},
  journal={Biomarkers},
  year={2013},
  volume={18},
  pages={88 - 94}
}
Context: TK1 found to be elevated biomarker in many solid cancers. Objectives: The study aimed to assess the prognostic significance of a serum TK1 in patients with metastatic NSCLC. Methods: The study included 48 consecutive patients, newly diagnosed with metastatic NSCLC, and 10 healthy volunteers. Serum TK1 activity determined by ELISA method. Results: Patients with a bTK1 level >156 Du L–1 had significantly shorter survival. TK1 level showed a strong correlation with primary tumor SUVmax… 

Serum Thymidine Kinase 1 Activity in the Prognosis and Monitoring of Chemotherapy in Lung Cancer Patients: A Brief Report

  • B. NismanH. Nechushtan T. Peretz
  • Medicine, Biology
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • 2014
TLDR
Elevated pretreatment serum TK1 activity was an independent, adverse prognostic factor, based on survival, in the two main histological types of LC.

Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial

TLDR
Results suggest that TK1 activity measured by DiviTum™ predicted therapy response, PFS and OS in loco regional inoperable or disseminated breast cancer, and this factor is a useful serum marker.

TK1 overexpression is associated with the poor outcomes of lung cancer patients: a systematic review and meta-analysis.

TLDR
The TK1 expression might have a supportive implication in assessing biological behavior and prognosis of lung cancer patients and be associated with poorer overall survival in patients with lung cancer.

Serum thymidine kinase 1 activity as a pharmacodynamic marker of cyclin-dependent kinase 4/6 inhibition in patients with early-stage breast cancer receiving neoadjuvant palbociclib

TLDR
Serum TK1 activity is a promising pharmacodynamic marker of palbociclib in ER+ breast cancer, and its value in predicting response to CDK4/6 inhibitors warrants further investigation.

The assay and clinical significance of serum thymidine kinase 1 in patients with colorectal carcinoma

TLDR
The detection of serum thymidine kinase 1 might have high clinical value in auxiliary diagnosis, curative effect monitoring, and prognosis judgment of colorectal carcinoma.

Diagnostic implications of the molecular forms and levels of serum thymidine kinase 1 in different canine malignancies

TLDR
Overall, the results demonstrate that TK1 protein assays provide valuable diagnostic information in a variety of canine malignancies.

Elevated transcriptional levels of aldolase A (ALDOA) associates with cell cycle-related genes in patients with NSCLC and several solid tumors

TLDR
ALDOA could contribute to the progress of cancer, at least partially through its association with genes relevant to cell cycle independent of glycolysis, as well as with CDC45 and CCNB2 in breast tumors.

Screening of Critical Genes in Lung Adenocarcinoma via Network Analysis of Gene Expression Profile

TLDR
A number of differentially expressed genes (DEGs) were identified for lung adenocarcinoma via comparative analysis of gene expression data, beneficial in deepening the understandings about the pathogenesis and providing directions for future researches.

Changed Expression of Cytoskeleton Proteins During Lung Injury in a Mouse Model of Streptococcus pneumoniae Infection

TLDR
Important changes in the protein profiles during pneumococcal infection mainly associated with regulation of vesicle-mediated transport, wound healing, and cytoskeleton organization are found.

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