Serum-stimulated cell cycle entry promotes ncOGT synthesis required for cyclin D expression

@inproceedings{Stichelen2012SerumstimulatedCC,
  title={Serum-stimulated cell cycle entry promotes ncOGT synthesis required for cyclin D expression},
  author={St{\'e}phanie Olivier-Van Stichelen and Ludivine Drougat and Vanessa Dehennaut and Ikram El Yazidi-Belkoura and C{\'e}line Guinez and A-M Mir and J-C Michalski and A-S Vercoutter-Edouart and Thomas Lefebvre},
  booktitle={Oncogenesis},
  year={2012}
}
Nuclear and cytoplasmic O-GlcNAc transferase (OGT) is a unique and universally expressed enzyme catalyzing O-GlcNAcylation of thousands of proteins. Although OGT interferes with many crucial intracellular processes, including cell cycle, only few studies have focused on elucidating the precise role of the glycosyltransferase during cell cycle entry. We first demonstrated that starved MCF7 cells reincubated with serum quickly induced a significant OGT increase concomitantly to activation of PI3K… CONTINUE READING
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