Serum sphingolipidomic analyses reveal an upregulation of C16- ceramide and sphingosine-1-phosphate in hepatocellular carcinoma

@inproceedings{Grammatikos2016SerumSA,
  title={Serum sphingolipidomic analyses reveal an upregulation of C16- ceramide and sphingosine-1-phosphate in hepatocellular carcinoma},
  author={Georgios Grammatikos and Niklas Schoell and Nerea Ferreir{\'o}s and Delphine Bon and E Weber Herrmann and Harald Farnik and Verena Koeberle and Albrecht Piiper and Stefan Zeuzem and Bernd Kronenberger and Oliver B. Waidmann and Josef Martin Pfeilschifter},
  booktitle={Oncotarget},
  year={2016}
}
We have recently shown that major alterations of serum sphingolipid metabolites in chronic liver disease associate significantly with the stage of liver fibrosis in corresponding patients. In the current study we assessed via mass spectrometry serum concentrations of sphingolipid metabolites in a series of 122 patients with hepatocellular carcinoma (HCC) compared to an age- and sex-matched series of 127 patients with cirrhosis. We observed a highly significant upregulation of long and very long… CONTINUE READING

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