Serum somatomedin binding proteins: physiologic significance and interference in radioligand assay.

@article{Daughaday1987SerumSB,
  title={Serum somatomedin binding proteins: physiologic significance and interference in radioligand assay.},
  author={William H. Daughaday and Madhavi Kapadia and I K Mariz},
  journal={The Journal of laboratory and clinical medicine},
  year={1987},
  volume={109 3},
  pages={355-63}
}
Mammalian sera contain binding proteins that specifically complex with somatomedins (insulin-like growth factor I and II) so that there are no detectable free somatomedins. There is immunologic evidence of two distinct types of serum binding proteins. The major binding protein complex (150,000 Mr) is growth hormone dependent. Binding proteins protect… CONTINUE READING