Serum-soluble c-kit levels during mobilization of peripheral blood stem cells correlate with stem cell yield.

@article{Ishiga2000SerumsolubleCL,
  title={Serum-soluble c-kit levels during mobilization of peripheral blood stem cells correlate with stem cell yield.},
  author={Kiyomi Ishiga and Toshio Kawatani and Fumihito Tajima and Hiromi Omura and Eiji Nanba and Hirohide Kawasaki},
  journal={International journal of hematology},
  year={2000},
  volume={72 2},
  pages={186-93}
}
c-Kit is expressed in hematopoietic stem cells and plays an important role in hematopoiesis. In 16 patients with malignancies, serum-soluble c-Kit levels and the expressions of c-KIT messenger RNA (mRNA) and protein in peripheral blood mononuclear cells were analyzed serially during 26 courses of peripheral blood stem cell (PBSC) mobilization after granulocyte colony-stimulating factor administration following chemotherapy for PBSC harvest. Serum-soluble c-Kit levels were significantly lower in… CONTINUE READING