Serum soluble TNF receptor I and II levels correlate with disease activity in IBD patients.

@article{Spoettl2007SerumST,
  title={Serum soluble TNF receptor I and II levels correlate with disease activity in IBD patients.},
  author={Tanja Spoettl and Martin Hausmann and Frank H. Klebl and Andrea Dirmeier and Bodo Klump and J{\"o}rg Hoffmann and Hans Herfarth and Antje Timmer and Gerhard Rogler},
  journal={Inflammatory bowel diseases},
  year={2007},
  volume={13 6},
  pages={
          727-32
        }
}
BACKGROUND Tumor necrosis factor alpha (TNFalpha) is a proinflammatory cytokine and an important mediator in the pathophysiology of inflammatory bowel disease (IBD). The effects of TNFalpha are mediated by 2 specific receptors, a 55-kDa protein (TNF-RI) and a 75-kDa receptor (TNF-RII), which are usually bound to the cell surface. Soluble TNF receptors I and II (sTNF-RI + II) are released by proteolytic cleavage of the extracellular domains of these receptors. Soluble TNF-Rs act as TNF… CONTINUE READING

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