Serum sickness‐like syndrome associated with cefaclor therapy

@article{Parra1992SerumSS,
  title={Serum sickness‐like syndrome associated with cefaclor therapy},
  author={F M Parra and Juan Manuel Igea and J A Mart{\'i}n and Mar{\'i}a Dolores Alonso and Apolinar Lezaun and T. Sainz},
  journal={Allergy},
  year={1992},
  volume={47}
}
We describe 2 cases of paediatric patients who developed the main clinical features of a serum sickness reaction, while on treatment with cefaclor. A decrease in complement values was observed in both eases. Physicians should be aware of the possibility of such drug adverse reaction. 
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To review presentations with adverse joint and skin reactions associated with the use of oral antibiotics, to describe the clinical course of children with cefaclor‐related serum sickness‐like reactions and compare these with cases reported to the Adverse Drug Reactions Advisory Committee (ADRAC).
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This clinical entity results from the formation and deposition of detectable antigen-antibody complexes in blood vessels, which results in clinical disease from 1 to 3 weeks, but usually 7 to 10 days after exposure to the antigen.
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TLDR
Observations suggest that new trends in antibiotic allergy may be appearing, whether such trends are worldwide or whether there is variability from country to country is not yet known.
Phenotypes and Natural Evolution of Drug Hypersensitivity
TLDR
This review summarises the complexity of DHR phenotyping, which can be based on different criterions as chronology, mechanism and clinical symptoms as well as natural evolution.
FORMULATION, DEVELOPMENT AND EVALUATION OF CEFACLOR EXTENDED RELEASE MATRIX TABLET
Cefaclor is a second generation cephalosporin antibiotics chemically related to penicillins widely used in treatment of respiratory, urinary and skin infections most affective against gram negative…
alidation of New RP-HPLC Method for the Pharmaceutical Dosage forms and in Human
A simple, rapid and precise reverse phase high performance liquid chromatography method has been developed and validated for the determination of Cefaclor in performed by Shimadzu model LC-20 AT…
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