Serum sickness‐like syndrome associated with cefaclor therapy

@article{Parra1992SerumSS,
  title={Serum sickness‐like syndrome associated with cefaclor therapy},
  author={F M Parra and Juan Manuel Igea and J A Mart{\'i}n and Mar{\'i}a Dolores Alonso and Apolinar Lezaun and T. Sainz},
  journal={Allergy},
  year={1992},
  volume={47}
}
We describe 2 cases of paediatric patients who developed the main clinical features of a serum sickness reaction, while on treatment with cefaclor. A decrease in complement values was observed in both eases. Physicians should be aware of the possibility of such drug adverse reaction. 
Adverse skin and joint reactions associated with oral antibiotics in children: The role of cefaclor in serum sickness‐like reactions
TLDR
To review presentations with adverse joint and skin reactions associated with the use of oral antibiotics, to describe the clinical course of children with cefaclor‐related serum sickness‐like reactions and compare these with cases reported to the Adverse Drug Reactions Advisory Committee (ADRAC).
Cefaclor and Serum Sickness-Like Reaction-Reply
TLDR
This clinical entity results from the formation and deposition of detectable antigen-antibody complexes in blood vessels, which results in clinical disease from 1 to 3 weeks, but usually 7 to 10 days after exposure to the antigen.
Recognising Antibacterial Hypersensitivity In Children
TLDR
Patch testing seems to be useful in diagnosing maculopapular reactions to systemically administered aminopenicillins, and in the acute phase, serum tryptase and urinary N-methylhistamine assays are reliable indiagnosing type I pathogenic mechanisms in immediate reactions.
Epidemiology of adverse cutaneous reactions to drugs.
Allergic reactions to penicillins. A changing world?
TLDR
Observations suggest that new trends in antibiotic allergy may be appearing, whether such trends are worldwide or whether there is variability from country to country is not yet known.
Phenotypes and Natural Evolution of Drug Hypersensitivity
TLDR
This review summarises the complexity of DHR phenotyping, which can be based on different criterions as chronology, mechanism and clinical symptoms as well as natural evolution.
FORMULATION, DEVELOPMENT AND EVALUATION OF CEFACLOR EXTENDED RELEASE MATRIX TABLET
Cefaclor is a second generation cephalosporin antibiotics chemically related to penicillins widely used in treatment of respiratory, urinary and skin infections most affective against gram negative
alidation of New RP-HPLC Method for the Pharmaceutical Dosage forms and in Human
A simple, rapid and precise reverse phase high performance liquid chromatography method has been developed and validated for the determination of Cefaclor in performed by Shimadzu model LC-20 AT
...
1
2
...

References

SHOWING 1-10 OF 11 REFERENCES
Serum sickness‐like syndrome associated with minocycline therapy
A 19 year‐old youth was taking oral minocycline and after 8 days he presented all four cardinal symptoms of serum sickness (urticaria, iewer, lymphadenopathy and joint symptoms). C3, C4 and CH50
Quantitative comparison of adverse reactions to cefaclor vs. amoxicillin in a surveillance study
  • L. R. Levine
  • Medicine, Biology
    Pediatric infectious disease
  • 1985
TLDR
During an 18-month adverse events surveillance period, children with a history of recurrent suspected or proved bacterial infections were treated with either cefaclor or amoxicillin and followed prospectively to determine the relative incidence and character of adverse events.
Rectal bleeding in the first month of life.
  • M. Levene
  • Medicine
    Postgraduate medical journal
  • 1979
TLDR
It is concluded that rectal bleeding in this age group is a relatively benign condition and in certain cases hospital admission may not be required.
Summary of laboratory studies on the antibacterial activity of cefaclor.
  • D. Preston
  • Biology, Medicine
    Postgraduate medical journal
  • 1979
TLDR
The useful antibacterial spectrum of cefaclor is shown to include all classes of bacteria that are generally susceptible to cephalothin and cephalexin and to be effective against many Enterobacteriaceae, Haemophilus sp.
High incidence of anaphylaetic reactions to cefaclor
  • Med Clin
  • 1986
Serum sickness, Ann Allergy
  • Med Clin
  • 1986
[Current aspects of serum sickness].
cefaclor vs amoxycillin in a surveillance study
  • Pediatr Infect Dis
  • 1985
...
1
2
...