Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis

  title={Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis},
  author={Y. Zhao and E. Samal and D. Srivastava},
  • Y. Zhao, E. Samal, D. Srivastava
  • Published 2005
  • Medicine, Biology
  • Nature
  • Gradients of signalling and transcription factors govern many aspects of embryogenesis, highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are phylogenetically conserved small RNAs that regulate the translation of target messenger RNAs, providing a mechanism for protein dose regulation. Here we show that microRNA-1-1 (miR-1-1) and miR-1-2 are specifically expressed in cardiac and skeletal muscle precursor cells. We found that the miR-1 genes are direct… CONTINUE READING

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