Serum response factor p67SRF is expressed and required during myogenic differentiation of both mouse C2 and rat L6 muscle cell lines

@article{Vandromme1992SerumRF,
  title={Serum response factor p67SRF is expressed and required during myogenic differentiation of both mouse C2 and rat L6 muscle cell lines},
  author={Marie Vandromme and C{\'e}cile Gauthier-Rouvi{\`e}re and Gilles Carnac and Ned J. C. Lamb and Anne Fernandez},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={118},
  pages={1489 - 1500}
}
The 67-kD serum response factor (p67SRF) is a ubiquitous nuclear transcription factor that acts by direct binding to a consensus DNA sequence, the serum response element (SRE), present in the promoter region of numerous genes. Although p67SRF was initially implicated in the activation of mitogen-stimulated genes, the identification of a sequence similar to SRE, the CArG box motif, competent to interact with SRE binding factors in many muscle-specific genes, has led to speculation that, in… CONTINUE READING