Serum response factor induces endothelial-mesenchymal transition in glomerular endothelial cells to aggravate proteinuria in diabetic nephropathy.

@article{Zhao2016SerumRF,
  title={Serum response factor induces endothelial-mesenchymal transition in glomerular endothelial cells to aggravate proteinuria in diabetic nephropathy.},
  author={Long Zhao and Jian Zhao and Xueling Wang and Zhixin Chen and Kexin Peng and Xiaohan Lu and Linghang Meng and Gang Liu and Guang-ju Guan and Fei Wang},
  journal={Physiological genomics},
  year={2016},
  volume={48 10},
  pages={
          711-718
        }
}
We investigated the expression and function of serum response factor (SRF) in endothelial-mesenchymal transition (EndMT) in glomerular endothelial cells (GEnCs) of diabetic nephropathy (DN). The expression of SRF, endothelial markers (VE-cadherin, CD31), and mesenchymal markers (α-SMA, FSP-1, fibronectin) was examined in GEnCs following high glucose or in renal cortex tissues of DN rats. SRF was upregulated by SRF plasmids and downregulated by CCG-1423 (a small molecule inhibitor of SRF) to… CONTINUE READING
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