Serum response factor has functional roles both in indirect binding to the CArG box and in the transcriptional activation function of human T-cell leukemia virus type I Tax.

@article{Fujii1994SerumRF,
  title={Serum response factor has functional roles both in indirect binding to the CArG box and in the transcriptional activation function of human T-cell leukemia virus type I Tax.},
  author={Masami Fujii and Haruka Tsuchiya and Tatsuya Chuhjo and Tohru Minamino and Keiichi Miyamoto and Motoharu Seiki},
  journal={Journal of virology},
  year={1994},
  volume={68 11},
  pages={7275-83}
}
We previously reported that Tax1 of human T-cell leukemia virus type I interacts directly with serum response factor (SRF) and that Tax1 activates the transcription of several cellular immediate-early genes through the SRF binding site (CArG box). This activation required the transcriptional activation function of Tax1, identified as an activity of GALTax (a chimeric Tax1 with the yeast transcription factor GAL4) at the GAL4-binding site. In this study, we examined whether SRF plays a role in… CONTINUE READING

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