Serum regulates Na+/H+ exchange in Caco-2 cells by a mechanism which is dependent on F-actin.

Abstract

Regulation of Na+/H+ exchange by fetal bovine serum was studied in Caco-2 cells, an established cell line derived from a human colon carcinoma. Cells were grown as polarized monolayers on collagen-coated filters and intracellular pH measured fluorometrically with 2',7'-bis(2-carboxymethyl)-5,6-carboxyfluorescein. Na+/H+ exchange was reduced 64% when cells… (More)

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@article{Watson1992SerumRN, title={Serum regulates Na+/H+ exchange in Caco-2 cells by a mechanism which is dependent on F-actin.}, author={A. J. Watson and Susan C. Levine and Mark Donowitz and Marshall H. Montrose}, journal={The Journal of biological chemistry}, year={1992}, volume={267 2}, pages={956-62} }