Serum protein pattern associated with organ damage and lupus nephritis in systemic lupus erythematosus revealed by PEA immunoassay

@inproceedings{Petrkov2017SerumPP,
  title={Serum protein pattern associated with organ damage and lupus nephritis in systemic lupus erythematosus revealed by PEA immunoassay},
  author={Anna Petr{\'a}{\vc}kov{\'a} and Andrea Smr{\vz}ov{\'a} and Petr Gajdos and Mark{\'e}ta Schubertov{\'a} and Petra Schneiderov{\'a} and Pavel Kromer and V{\'a}clav Sn{\'a}sel and Martina Sk{\'a}celov{\'a} and Frantisek Mrazek and Josef Zadra{\vz}il and Pavel Hor{\'a}k and Eva Kriegova},
  booktitle={Clinical Proteomics},
  year={2017}
}
BackgroundSystemic lupus erythematosus (SLE) is a remarkably heterogeneous autoimmune disease. Despite tremendous efforts, our knowledge of serum protein patterns in severe SLE phenotypes is still limited. We investigated the serum protein pattern of SLE, with special emphasis on irreversible organ damage and active lupus nephritis (LN) as assessed by renal Systemic Lupus Erythematosus Disease Activity Index.MethodsWe used proximity extension immunoassay (PEA, Proseek Multiplex, Olink) to… CONTINUE READING

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