Serum prostate-specific antigen hemodilution among obese men undergoing screening in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

@article{Grubb2009SerumPA,
  title={Serum prostate-specific antigen hemodilution among obese men undergoing screening in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.},
  author={Robert L. Grubb and Amanda Black and Grant Izmirlian and Thomas P Hickey and Paul F. Pinsky and Jerome Mabie and Thomas L. Riley and Lawrence R Ragard and Philip C Prorok and C. T. van den Berg and E. David Crawford and Timothy Robert Church and Gerald L. Andriole},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2009},
  volume={18 3},
  pages={748-51}
}
BACKGROUND Previous studies have shown an inverse relationship between prostate-specific antigen (PSA) concentration and body mass index (BMI). It has been recently proposed that this relationship may be explained by the larger plasma volume of obese men diluting a fixed amount of PSA (hemodilution effect). We examined this hypothesis in a cohort of men enrolled in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. METHODS Of 38,349 men ages 55 to 74 years randomized… CONTINUE READING

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