Serum prolactin levels for differentiation of nonepileptic versus true seizures: limited utility

@article{Shukla2004SerumPL,
  title={Serum prolactin levels for differentiation of nonepileptic versus true seizures: limited utility},
  author={Garima Shukla and Manvir Bhatia and Subbiah Vivekanandhan and Nandita Gupta and Manjari Tripathi and Achal Kumar Srivastava and Ravindra M Pandey and Satish Jain},
  journal={Epilepsy \& Behavior},
  year={2004},
  volume={5},
  pages={517-521}
}

Serum prolactin level and lactate dehydrogenase activity in patients with epileptic and nonepileptic seizures

TLDR
It is demonstrated that serum LDH activities within 1 hour after the seizure appear to be increased in patients with ES compared with those with NES, suggesting the potential role ofLDH activities as a diagnostic tool in distinction of seizure types, and supports the hypothesis that LDH-antagonists may have a role in the management of seizure and epilepsy.

Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

TLDR
Serum neuroglobin may be a promising novel marker to differentiate epileptic versus nonepileptic disorders in children in the emergency setting, when history and clinical presentation are equivocal.

Treatment and Diagnosis of Psychogenic Nonepileptic Seizures

TLDR
Psychiatric evaluation of patients with PNES may be particularly helpful in elucidating the etiology and detecting comorbid diseases and may be helpful in the long-term treatment of these patients.

Epilepsy and psychogenic nonepileptic seizures

Psychogenic nonepileptic seizures.

TLDR
Treatment involves discontinuation of antiepileptic drugs in patients without concurrent epilepsy and referral for appropriate psychiatric care and more studies are needed to determine the best treatment modalities.

Psychogenic non-epileptic seizures (PNES) in the context of concurrent epilepsy – making the right diagnosis

TLDR
A narrative review summarises clinical, electrophysiological and historical features that can help identify patients with epilepsy and additional PNES.

References

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Serum prolactin levels are elevated also after pseudoepileptic seizures

Predictivity of Plasma Prolactin Levels in Differentiating Epilepsy from Pseudoseizures: A Prospective Study

TLDR
It is confirmed that plasma prolactin concentration is highly predictive of true epilepsy but barely predictive of pseudoseizures.

Plasma prolactin in epilepsy and pseudoseizures.

TLDR
Plasma prolactin levels were significantly (p < 0.001) elevated following generalized seizures but were almost normal following pseudoseizures, and may, therefore, be helpful in differentiating between generalized seizures and pseudoseIZures.

Serum prolactin concentrations are elevated after syncope

TLDR
It is indicated that elevated PRL concentrations are present after hypotensive syncope and are of little use in differentiating such syncope from epileptic seizures.

Serum prolactin levels after seizure and syncopal attacks

TLDR
It is concluded that the elevated serum prolactin level after an epileptic attack is of no significant value in differential diagnosis between epileptic and vaso-vagal syncopal attacks.

Comparison of the effects of frontal and temporal lobe partial seizures on prolactin levels.

TLDR
The acute effects of partial (focal) epileptic seizures on serum prolactin levels were studied in two groups of patients and a measurement will not help in the clinical differentiation of frontal lobe complex partial seizures from psychogenic attacks.

Prolactin and cortisol levels in seizure disorders.

TLDR
Levels of prolactin (PRL) and cortisol were estimated to find out the acute effects of generalised tonic clonic seizures, partial seizures and pseudoseizures in 60, 18 and 9 patients respectively and postictal PRL estimation can help in differentiating pseudoseIZures from GTCS.

The clinical features and prognosis of pseudoseizures diagnosed using video‐EEG telemetry

TLDR
It was shown that 40% of these patients stopped having pseudoseizures, and this favorable outcome was associated with being female, leading an independent life, a formal psychological approach to therapy and counseling, and the absence of coexisting epilepsy, but not with the duration of pseudoepilepsy, prior episodes of pseudostatus, the coexistence of overt psychiatric disease, or the clinical features of the attacks.

Prolaktin im Serum nach zerebralen und psychogenen Krampfanfällen im Kindes- und Jugendlichenalter―eine nützliche Zusatzmethode zur Unterscheidung zwischen beiden Anfallsformen

TLDR
Prolactin levels were measured immediately after the seizure in some, and 15 to 20 minutes later in all of 67 children aged between 6 months and 17 years, finding the method is useful in the differential diagnosis of epileptogenic versus psychogenic seizures.

Plasma prolactin concentrations following epileptic and pseudoseizures.

TLDR
Serial plasma prolactin levels were measured following eighteen generalised seizures, ten partial seizures and eight pseudoseizures to help in differentiating between generalised and pseudoseIZures.