Serum prolactin levels for differentiation of nonepileptic versus true seizures: limited utility

@article{Shukla2004SerumPL,
  title={Serum prolactin levels for differentiation of nonepileptic versus true seizures: limited utility},
  author={G. Shukla and M. Bhatia and S. Vivekanandhan and N. Gupta and M. Tripathi and Achal Srivastava and R. Pandey and Satish Jain},
  journal={Epilepsy \& Behavior},
  year={2004},
  volume={5},
  pages={517-521}
}
Frequently occurring nonepileptic psychogenic seizures (PNES) are a cause of substantial morbidity. Differentiation of these from true seizures may sometimes be very difficult. Serum prolactin level estimation following the event has been described as a useful test for this purpose. We conducted this study to assess the role of this test in diagnosis of PNES. Serum prolactin was estimated from venous blood samples of 19 patients (13 females, 6 males) with PNES and 17 patients (5 females, 12… Expand
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TLDR
The rather limited discriminative power of prolactin measurements makes it of questionable value in discerning between epileptic and pseudo-epileptic seizures. Expand
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It is confirmed that plasma prolactin concentration is highly predictive of true epilepsy but barely predictive of pseudoseizures. Expand
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Plasma prolactin levels were significantly (p < 0.001) elevated following generalized seizures but were almost normal following pseudoseizures, and may, therefore, be helpful in differentiating between generalized seizures and pseudoseIZures. Expand
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The acute effects of partial (focal) epileptic seizures on serum prolactin levels were studied in two groups of patients and a measurement will not help in the clinical differentiation of frontal lobe complex partial seizures from psychogenic attacks. Expand
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Prolactin levels were measured immediately after the seizure in some, and 15 to 20 minutes later in all of 67 children aged between 6 months and 17 years, finding the method is useful in the differential diagnosis of epileptogenic versus psychogenic seizures. Expand
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Serial plasma prolactin levels were measured following eighteen generalised seizures, ten partial seizures and eight pseudoseizures to help in differentiating between generalised and pseudoseIZures. Expand
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