Serum paraoxonase activity changes in patients with Alzheimer's disease and vascular dementia

@article{Paragh2002SerumPA,
  title={Serum paraoxonase activity changes in patients with Alzheimer's disease and vascular dementia},
  author={Gy{\"o}rgy J R Paragh and Petra Balla and Evelin Katona and Ildik{\'o} Seres and Anik{\'o} {\'E}gerh{\'a}zi and Istv{\'a}n Degrell},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2002},
  volume={252},
  pages={63-67}
}
The prevalence of Alzheimer's disease (AD) and vascular dementia (VAD) increases with aging of the population. The role of lipoproteins in the pathogenesis of AD is unclear: apoE2 offers protection and apoE3 is neutral, while apoE4 promotes the development of the disease. Recently, several studies have confirmed the role of oxidative stress in the pathogenesis of AD and VAD. HDL-associated paraoxonase is one of the antioxidative enzymes that may reduce LDL oxidation. In our study, we… CONTINUE READING
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