Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis.

@article{Gugliucci2011SerumP1,
  title={Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis.},
  author={Alejandro Gugliucci and Eriko Kinugasa and Kazuhiko Kotani and Russell J. Caccavello and Satoshi Kensuke Kimura},
  journal={Clinical chemistry and laboratory medicine},
  year={2011},
  volume={49 1},
  pages={61-7}
}
BACKGROUND The mechanism of paraoxonase 1 (PON1) atheroprotective remains elusive. The lactonizing/lactonase activity of PON1 is gaining favor as the most significant in physiology. METHODS We studied 42 end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) and 49 control subjects. We measured PON1 lactonase, arylesterase and triesterase activities by kinetic methods. RESULTS Serum lactonase activity was 11% lower in ESRD patients (p<0.0001) and did not correlate with high… CONTINUE READING

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