Serum osteoprotegerin levels in healthy controls and cancer patients.

  title={Serum osteoprotegerin levels in healthy controls and cancer patients.},
  author={Allan Lipton and Suhail Ali and Kim Leitzel and Vernon M. Chinchilli and Lois Witters and Linda L Engle and Donna L Holloway and Pirow Bekker and Colin Robert Dunstan},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={8 7},
PURPOSE Osteoprotegerin (OPG) is a novel secreted member of the tumor necrosis factor receptor superfamily. In vitro, OPG blocks osteoclastogenesis in a dose-dependent manner. Serum OPG levels were assayed in cancer patients and healthy control subjects using an ELISA. RESULTS OPG levels in healthy controls were significantly higher in sera (0.17 ng/ml) than in plasma (0.14 ng/ml). OPG levels did not differ by age in either control group. Serum was available from patients with solid tumors (n… CONTINUE READING
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