Serum osteoprotegerin/osteoclastogenesis-inhibitory factor during pregnancy and lactation and the relationship with calcium-regulating hormones and bone turnover markers.

@article{Uemura2002SerumOF,
  title={Serum osteoprotegerin/osteoclastogenesis-inhibitory factor during pregnancy and lactation and the relationship with calcium-regulating hormones and bone turnover markers.},
  author={Hirokazu Uemura and Toshiyuki Yasui and Masaaki Kiyokawa and Akira Kuwahara and Hiromichi Ikawa and Toshiya Matsuzaki and Masahiko Maegawa and Hiroko Furumoto and Minoru Irahara},
  journal={The Journal of endocrinology},
  year={2002},
  volume={174 2},
  pages={353-9}
}
Pregnancy and lactation induce dynamic changes in maternal bone and calcium metabolism. A novel cytokine termed osteoprotegerin (OPG)/osteoclastogenesis-inhibitory factor (OCIF) was recently isolated; this cytokine inhibits osteoclast maturation. To define the effects of pregnancy and lactation on circulating OPG/OCIF in mothers, we studied the changes in the levels of OPG/ OCIF as well as those of calcium-regulating hormones and biochemical markers of bone turnover in the maternal circulation… CONTINUE READING
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