Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.

@article{Pereira2016SerumOI,
  title={Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.},
  author={Thiago de Almeida Pereira and Wing-Kin Syn and Fausto Edmundo Lima Pereira and Jos{\'e} Roberto Lambertucci and W Evan Secor and Anna Mae Diehl},
  journal={International journal for parasitology},
  year={2016},
  volume={46 13-14},
  pages={
          829-832
        }
}
Schistosomiasis is a major cause of fibrosis and portal hypertension. The reason 4-10% of infected subjects develops hepatosplenic schistosomiasis remains unclear. Chronically infected male CBA/J mice reproduce the dichotomic forms of human schistosomiasis. Most mice (80%) develop moderate splenomegaly syndrome (similar to hepatointestinal disease in humans) and 20% present severe hypersplenomegaly syndrome (analogous to human hepatosplenic disease). We demonstrated that the profibrogenic… CONTINUE READING
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