Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori.

@article{Cover1992SerumNA,
  title={Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori.},
  author={Timothy L Cover and P Cao and Uma Murthy and Michael S Sipple and Martin J. Blaser},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 3},
  pages={913-8}
}
Approximately 50% of Helicobacter pylori isolates produce a cytotoxin in vitro that induces vacuolation of eukaryotic cells. To determine the in vivo relevance of this phenomenon, we sought to detect cytotoxin-neutralizing antibodies in sera from H. pylori-infected persons. As a group, sera from 29 H. pylori-infected patients neutralized the activity of the purified cytotoxin to a significantly greater extent than sera from 24 uninfected persons (P = 0.007). The cytotoxin neutralizing activity… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Helicobacterpylori infection and gastric carcinoma among Japanese - Americans in Hawaii

A. R. Zinsmeister, E. P. DiMagno, A. Weaver, G. I. Perez-Perez, M. J. Blaser
N . Engl . J . Med . • 1991

Helicobacterpylori infection and the risk of gastric carcinoma . 199 1

I. Kato, G. I. Perez-Perez, M. J. Blaser
N . Engl . J . Med . • 1991

In vitro cytotoxin production by Helicobacter pylori strains and clinical correlations

R. D. Leunk, M. A. Ferguson, D. R. Morgan, D. E. Low, A. E. Simor
Microb . Ecol . Health Dis . • 1991

Similar Papers

Loading similar papers…