Serum microRNAs in male subfertility—biomarkers and a potential pathogenetic link to metabolic syndrome

@article{Trzybulska2017SerumMI,
  title={Serum microRNAs in male subfertility—biomarkers and a potential pathogenetic link to metabolic syndrome},
  author={D. Trzybulska and J. Bobjer and A. Giwercman and C. Tsatsanis},
  journal={Journal of Assisted Reproduction and Genetics},
  year={2017},
  volume={34},
  pages={1277 - 1282}
}
PurposeThe purpose of the study was to identify serum microRNAs providing a link between male subfertility and metabolic syndrome (MetS) and validate their diagnostic potential.MethodsSera were analyzed for fertility and MetS-related parameters in subfertile men (n = 79) and controls (n = 38). Literature review identified miR-155-5p, miR-122-5p, miR-200a-3p, and miR-200c-3p which previously were associated with parameters of fertility as well as metabolic disorders. They were measured in the… Expand
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References

SHOWING 1-10 OF 31 REFERENCES
Serum miR-155 as a potential biomarker of male fertility.
TLDR
Association of the inflammatory miRNA miR-155 with male fertility contributes to the understanding of the pathophysiology of subfertility and suggests a novel biomarker of male fertility. Expand
Panel of five microRNAs as potential biomarkers for the diagnosis and assessment of male infertility.
TLDR
The finding suggests that these five miRNAs have potential as novel noninvasive biomarkers to diagnose patients with subfertility and the combination with other conventional tests would improve the diagnostic accuracy for detecting patients with different forms of NOA. Expand
Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p.
TLDR
The profiling of these three identified sp-miRNAs provides a novel noninvasive, semen-based test for NOA diagnosis and it is proposed that they may participate in a methylation-miRNA-gene network related to NOA development. Expand
Seminal plasma microRNAs: potential biomarkers for spermatogenesis status.
TLDR
Aberrant over-expression levels of miR-19b and let-7a may be an indicator of spermatogenic failure in fertile men and idiopathic infertile patients with oligozoospermia and non-obstructive azoospermia using quantitative real-time PCR. Expand
Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver.
TLDR
Serum levels of miRNAs, particularly miR-122, may be a useful biomarker for NAFLD and was correlated with the severity of liver steatosis. Expand
Altered of microRNA expression level in oligospermic patients
TLDR
The study showed that mir-21 and mir-22 are indirectly involved in spermatogenesis by regulating of the estrogen receptor and might have a diagnostic and prognostic value in men infertility. Expand
Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility.
TLDR
The measurement of miRNAs in seminal plasma provides a novel, noninvasive approach for diagnosing male infertility. Expand
Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments.
TLDR
The results reveal an extended number of miRNAs that were differentially expressed in asthenozoospermic and oligoasthenozoespermic males compared with normozoos permic males and provide evidence for analysis of miRNA profiles as a future diagnosing tool for male infertility. Expand
Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults.
TLDR
Elevated circulating miR-122 is positively associated with obesity and insulin resistance in young adults and provides a better understanding regarding the role of miRNAs in adiposity and insulin sensitivity. Expand
Aberrant Hepatic MicroRNA Expression in Nonalcoholic Fatty Liver Disease
TLDR
Interestingly, the expression levels of these six miRNAs were increased in HepG2 cells and human hepatocytes after treatment with FFAs and proinflammatory factors, which suggest a critical role for mi RNAs in the pathogenesis of NAFLD. Expand
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