Serum matrix metalloproteinases in adult CF patients: Relation to pulmonary exacerbation.


BACKGROUND Matrix metalloproteinases (MMPs) virtually degrade all components of the extracellular matrix and are mainly expressed in tissues following inflammation or remodeling. Increased expression of certain MMPs in sputum and bronchoalveolar lavage of patients with cystic fibrosis (CF) is related to impaired lung function. We investigated whether a… (More)
DOI: 10.1016/j.jcf.2009.06.001


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