Serum matrix metalloproteinase-3 and fibrin degradation product levels correlate with clinical disease activity in rheumatoid arthritis.

@article{Ichikawa1998SerumMM,
  title={Serum matrix metalloproteinase-3 and fibrin degradation product levels correlate with clinical disease activity in rheumatoid arthritis.},
  author={Y. S. Ichikawa and Chiho Yamada and Terumi Horiki and Yuuichi Hoshina and Makoto Uchiyama},
  journal={Clinical and experimental rheumatology},
  year={1998},
  volume={16 5},
  pages={533-40}
}
OBJECTIVE Plasmin and matrix metalloproteinase-3 (MMP-3) have been linked to articular destruction in rheumatoid arthritis (RA). We compared circulating levels of plasmin-mediated fibrin degradation product (FDP D-dimer) and MMP-3 with traditional parameters of disease activity in RA to determine their clinical utility. MATERIALS AND METHODS Serum levels of MMP-3 and D-dimer were determined by enzyme-linked immunoassays in 60 patients with RA. Twenty healthy females and 21 patients with… CONTINUE READING