Serum markers of lipid peroxidation, antioxidant enzymatic defense, and collagen degradation in an experimental (Pond-Nuki) canine model of osteoarthritis.

@article{Goranov2007SerumMO,
  title={Serum markers of lipid peroxidation, antioxidant enzymatic defense, and collagen degradation in an experimental (Pond-Nuki) canine model of osteoarthritis.},
  author={Nikolay V. Goranov},
  journal={Veterinary clinical pathology},
  year={2007},
  volume={36 2},
  pages={192-5}
}
BACKGROUND Chondrocyte lipid peroxidation is strongly suggested to mediate collagen degradation and thus, to be involved in the pathogenesis of cartilage degradation and osteoarthritis (OA). OBJECTIVES The objective of this study was to evaluate early changes in serum biochemical indicators of oxidative stress during the development of OA in a canine model. METHODS Experimental OA was induced in 7 dogs by transection of the anterior cruciate ligament (Pond-Nuki model). Venous blood samples… CONTINUE READING

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