Serum lipids and hippocampal volume: The link to Alzheimer's disease?

@article{Wolf2004SerumLA,
  title={Serum lipids and hippocampal volume: The link to Alzheimer's disease?},
  author={Henrike Wolf and Anke Hensel and Thomas Arendt and Miia Kivipelto and Bengt Winblad and H. -J. Gertz},
  journal={Annals of Neurology},
  year={2004},
  volume={56}
}
The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol was studied in 86 elderly subjects with a range of cognitive functions. High‐density lipoprotein cholesterol, but not low‐density lipoprotein cholesterol or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of high‐density… 
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Significant correlations were found between cholesterol precursors lathosterol, lanosterol and 24S-hydroxycholesterol (a putative marker of brain cholesterol turnover) in plasma and brain atrophy as quantified by MRI.
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Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review
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An association between plasma lipids, polymorphisms in genes associated with cholesterol transport, and Alzheimer's disease is found, proving that plasmalipids can be used as biomarkers for early diagnosis of Alzheimer’s disease.
Association of cardiovascular factors and Alzheimer's disease plasma amyloid-beta protein in subjective memory complainers.
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A novel negative association between HDL and Abeta is reported, which if demonstrated to be causal has implications for the development of lifestyle interventions and/or novel therapeutics.
Low-Density Lipoprotein Cholesterol and Alzheimer's Disease: A Systematic Review and Meta-Analysis
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Elevated concentration of LDL-c (>121 mg/dl) may be a potential risk factor for AD, and this association is strong in patients aged 60–70 years, but vanishes with advancing age.
High‐density lipoprotein‐related cholesterol metabolism in Alzheimer’s disease
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The pathway that leads to HDL formation and its subsequent remodelling and catabolism is discussed with regards to the possible involvement of HDL ‘protein cargo’ in Alzheimer's disease.
Elevated HDL Levels Linked to Poorer Cognitive Ability in Females With Parkinson’s Disease
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Higher serum HDL associates with poorer cognitive function in females with PD and presents a sex-specific biomarker for cognitive impairment in PD.
Cholesterol and Late-Life Cognitive Decline
TLDR
Factors that influence cholesterol metabolism, such as dietary intake, are shown to play a role in late-life cognitive function and the risk of dementia, but the association is strongly age-dependent.
The influence of age on the association between cholesterol and cognitive function
Circulating biomarkers of cognitive decline and dementia.
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