Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia.

@article{Schulz2002SerumLO,
  title={Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia.},
  author={Richard Schulz and Christoph Hummel and Sabine Heinemann and Werner Seeger and Friedrich Grimminger},
  journal={American journal of respiratory and critical care medicine},
  year={2002},
  volume={165 1},
  pages={67-70}
}
Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality; however, some patients with OSA do not develop cardiovascular disease even in the presence of severe nocturnal oxygen desaturations. Vascular endothelial growth factor (VEGF) is a hypoxia-sensitive glycoprotein stimulating neoangiogenesis. We hypothesized that VEGF production is increased in OSA because of repetitive nocturnal hypoxia. Three different groups were investigated: 10 OSA patients with… CONTINUE READING
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