Serum levels of tumor necrosis factor-alpha are increased in obese patients with noninsulin-dependent diabetes mellitus.

@article{Katsuki1998SerumLO,
  title={Serum levels of tumor necrosis factor-alpha are increased in obese patients with noninsulin-dependent diabetes mellitus.},
  author={Akira Katsuki and Yasuhiro Sumida and Shuichi Murashima and Kazuhiko Murata and Yutaka Takarada and Ken R. Ito and Masahiko Fujii and Kazufumi Tsuchihashi and Hiroyuki Goto and Kaname Nakatani and Yutaka Yano},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 3},
  pages={859-62}
}
To clarify the significance of the serum levels of tumor necrosis factor-alpha (TNF-alpha) in the mechanism of insulin resistance, we studied 12 obese patients with noninsulin-dependent diabetes mellitus (NIDDM). We evaluated the relationship of TNF-alpha levels with the visceral, subcutaneous, and total fat areas measured by computed tomography (CT), and with insulin resistance evaluated by the glucose infusion rate (GIR) observed during an euglycemic hyperinsulinemic clamp study. Controls… CONTINUE READING

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References

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Tumor necrosis factor-a and hyperglycemia-induced insulin resistance, evidence for different mechanisms and different effects on insulin signaling

G Kroder, B Bossenmainer, M Kellerer
J Clin Invest. 97:1471–1477 • 1996
View 1 Excerpt

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