Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma.

@article{Kohga2008SerumLO,
  title={Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma.},
  author={Keisuke Kohga and Tetsuo Takehara and Tomohide Tatsumi and Kazuyoshi Ohkawa and T. Esashi Miyagi and Naoki Hiramatsu and Tatsuya Kanto and Tsutomu Kasugai and Kazuhiro Katayama and Michio Kato and Norio Hayashi},
  journal={Cancer science},
  year={2008},
  volume={99 8},
  pages={1643-9}
}
Soluble forms of major histocompatibility complex (MHC) class I-related chain A and B (MICA/B) are increased in the sera of patients with malignancy and impair the antitumor immune response by downregulating expression of their cognate immunoreceptor natural killer group 2, member D (NKG2D). Recently, soluble MICA/B were reported to appear even in some premalignant diseases, raising questions about the impact of soluble MICA/B produced from tumors on the expression of NKG2D. The present study… CONTINUE READING
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