Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward

@inproceedings{Bacon2012SerumLO,
  title={Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward},
  author={Siobh{\'a}n Bacon and Ma Peyh Kyithar and Jasmin Schmid and Syed Shakeel Raza Rizvi and Caroline K. Bonner and Rolf E. Graf and Jochen H. M. Prehn and Maria M. Byrne},
  booktitle={BMC endocrine disorders},
  year={2012}
}
BACKGROUND Mutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A) result in the commonest type of maturity onset diabetes of the young (MODY). HNF1A-MODY carriers have reduced pancreatic beta cell mass, partially due to an increased rate of apoptosis. To date, it has not been possible to determine when apoptosis is occurring in HNF1A-MODY.We have recently demonstrated that beta cell apoptosis stimulates the expression of the pancreatic stone protein/regenerating (PSP… CONTINUE READING
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