Serum levels of osteopontin are increased in SIRS and sepsis

  title={Serum levels of osteopontin are increased in SIRS and sepsis},
  author={Rosanna R Vaschetto and Stefania Nicola and Carlo Olivieri and Elena Boggio and Fabio Piccolella and Riccardo Mesturini and Federica Damnotti and Davide Colombo and Paolo Navalesi and F. Della Corte and Umberto Dianzani and Annalisa Chiocchetti},
  journal={Intensive Care Medicine},
In sepsis, dysregulation of the immune response leads to rapid multiorgan failure and death. Accurate and timely diagnosis is lifesaving and should discriminate sepsis from the systemic inflammatory response syndrome (SIRS) caused by non-infectious agents. Osteopontin acts as an extracellular matrix component or a soluble cytokine in inflamed tissues. Its exact role in immune response and sepsis remains to be elucidated. Therefore, we investigated the role of osteopontin in SIRS and sepsis… CONTINUE READING