Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites

@article{Mantovani2000SerumLO,
  title={Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites},
  author={Giovanni Mantovani and Antonio Macci{\`o} and Loredana Mura and E. Rabino Massa and Maria Caterina Mudu and C. Garc{\'i}a Mulas and Maria Rita Lusso and Clelia Madeddu and Annita Dess{\`i}},
  journal={Journal of Molecular Medicine},
  year={2000},
  volume={78},
  pages={554-561}
}
Leptin is a recently identified hormone produced by the adipocyte ob gene which acts as a negative feedback signal critical to the normal control of food intake and body weight. A number of proinflammatory cytokines, such as interleukin (IL) 1α, IL-6, tumor necrosis factor (TNF) α and interferon (IFN) γ, have been proposed as mediators of cancer cachexia. These data suggest that abnormalities in leptin production/release or in its feedback mechanism play a role in cancer patients. To elucidate… CONTINUE READING
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