Serum levels of insulin-like growth factor-I are related to age and not to body composition in healthy women and men.

@article{OConnor1998SerumLO,
  title={Serum levels of insulin-like growth factor-I are related to age and not to body composition in healthy women and men.},
  author={Kieran G. O'Connor and Jordan D. Tobin and S. Mitchell Harman and Chris C. Plato and Tracey A. Roy and Sherry Sherman and Marc R. Blackman},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={1998},
  volume={53 3},
  pages={
          M176-82
        }
}
BACKGROUND Aging is accompanied by decreased bone and lean body mass, increased fat mass, and reduced growth hormone (GH) axis function, reflected in diminished levels of insulin-like growth factor-I (IGF-I). Similar changes in body composition occur in nonelderly, GH-deficient adults and are reversible with GH administration, suggesting that diminished GH/IGF-I axis activity may contribute to such age-related changes. To determine the precise pattern of IGF-I decline with age, and to test the… CONTINUE READING

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